艾德里安·蒙克（阿蒙）曾是旧金山警局侦探，他具有对事物观察细致入微、过目不忘的天赋和高超的破案头脑，他以独特的破案方法破获不少棘手案件，是有名的侦探。几年前阿蒙深爱的妻子被炸弹意外炸死，巨大的打击使他患上了一种强迫症——异常洁癖，极度不能容忍杂乱肮脏无序的环境，畏高，对许多微生物心理过敏，害怕人群……这些奇怪的症状让他无法再胜任警队的职务，他在护士（后来成为了他的助手）沙伦娜的协助下，开设了私人侦探所。两人就像神经版的福尔摩斯和女性版的华生医生，和探长斯塔迈尔以及副手兰迪继续侦破种种奇异的案件，同时，蒙克下决心要找到杀死他妻子的凶手……

Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective." 　　Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.

《超感警探》由获得金球奖提名的Simon Baker饰演Patrick Jane。在此片中Patrick Jane 是一名加利福尼亚调查局（CBI）的独立咨询师，凭借超然卓绝的观察能力破获了多个重大罪案，取得了辉煌战绩。但在局里，由于无所顾忌的我行我素和以前火热一时的明星灵媒经历，Jan可谓是声名狼籍，没什么好口碑。当然，他现在肯承认那些超能力都是他装出来的了。虽然Jane在破获一系列难度高、影响大的案件中所起的作用获得了同事们的高度评价，但是，严谨的高级警探Teresa Lisbon却一点也不想自己的团队里有他这个人，她对此毫不隐瞒而且身体力行，尽管如此，她还是不得不承认他确实对破案有帮助，可承认归承认，承认的同时，她仍然会毫不留情的对他的做秀，自恋和危险的缺乏约束进行狂轰乱炸。上司如此，下属也是一样，Lisbon的团队，警探Kimball Cho,，Wayne Rigsby和菜鸟Grace Van Pelt都认为Jane 是一个危害团队的无缰之马，但同时又都对他的魅力和办案的能力赞叹不已。

《超感警探》由获得金球奖提名的Simon Baker饰演Patrick Jane。在此片中Patrick Jane 是一名加利福尼亚调查局（CBI）的独立咨询师，凭借超然卓绝的观察能力破获了多个重大罪案，取得了辉煌战绩。但在局里，由于无所顾忌的我行我素和以前火热一时的明星灵媒经历，Jan可谓是声名狼籍，没什么好口碑。当然，他现在肯承认那些超能力都是他装出来的了。虽然Jane在破获一系列难度高、影响大的案件中所起的作用获得了同事们的高度评价，但是，严谨的高级警探Teresa Lisbon却一点也不想自己的团队里有他这个人，她对此毫不隐瞒而且身体力行，尽管如此，她还是不得不承认他确实对破案有帮助，可承认归承认，承认的同时，她仍然会毫不留情的对他的做秀，自恋和危险的缺乏约束进行狂轰乱炸。上司如此，下属也是一样，Lisbon的团队，警探Kimball Cho,，Wayne Rigsby和菜鸟Grace Van Pelt都认为Jane 是一个危害团队的无缰之马，但同时又都对他的魅力和办案的能力赞叹不已。

《超感警探》由获得金球奖提名的Simon Baker饰演Patrick Jane。在此片中Patrick Jane 是一名加利福尼亚调查局（CBI）的独立咨询师，凭借超然卓绝的观察能力破获了多个重大罪案，取得了辉煌战绩。但在局里，由于无所顾忌的我行我素和以前火热一时的明星灵媒经历，Jan可谓是声名狼籍，没什么好口碑。当然，他现在肯承认那些超能力都是他装出来的了。虽然Jane在破获一系列难度高、影响大的案件中所起的作用获得了同事们的高度评价，但是，严谨的高级警探Teresa Lisbon却一点也不想自己的团队里有他这个人，她对此毫不隐瞒而且身体力行，尽管如此，她还是不得不承认他确实对破案有帮助，可承认归承认，承认的同时，她仍然会毫不留情的对他的做秀，自恋和危险的缺乏约束进行狂轰乱炸。上司如此，下属也是一样，Lisbon的团队，警探Kimball Cho,，Wayne Rigsby和菜鸟Grace Van Pelt都认为Jane 是一个危害团队的无缰之马，但同时又都对他的魅力和办案的能力赞叹不已。